国立研究開発法人土木研究所

論文・刊行物検索

利用者の方へ

詳細情報

論文投稿 A new method to search for per- and polyfluoroalkyl substances (PFASs) by linking fragmentation flags with their molecular ions by drift time using ion mobility spectrometry

作成年度 2019 年度
論文名 A new method to search for per- and polyfluoroalkyl substances (PFASs) by linking fragmentation flags with their molecular ions by drift time using ion mobility spectrometry
論文名(和訳)
論文副題
発表会
誌名 Chemosphere
巻・号・回 239 
発表年月日 2019/08/01
所属研究室/機関名 著者名(英名)
Kyoto UniversitySatoru YUKIOKA
Kyoto UniversityShuhei TANAKA
Public Works Research InstituteYuji SUZUKI
Kyoto UniversityShigeo FUJII
Kyoto UniversityShinya ECHIGO
抄録
Per- and polyfluoroalkyl substances (PFASs) are a group of anthropogenic organic fluorinated compounds that have been detected widely. To discover unknown PFASs, previous researchers have applied high-resolution mass spectrometer using fragmentation flagging approach with common fragment ion at the same retention time as the flags. However, it was difficult to search for their molecular ion from co-eluting peaks in the full-scan spectrum at a specific retention time. Here, we attempted to utilize drift time acquired by ion mobility spectrometry for making linkages between fragment ions and their molecular ions. For validating the process, standard solution spiked with PFASs were analyzed by liquid chromatography/ion mobility ? quadrupole time-of-flight mass spectrometry (LC/IM-QTOF-MS). Fluorinated fragment ions (fragmentation flags) were categorized into three classes: Class 1 (120 types of [CxFy]?), Class 2 (123 types of [CxFyO]?), Class 3 (131 types of [CxFyO3S]?) and all overlapping fragmentation flags detected at an identical retention time were bundled together as a “flag set”. Injecting standard mixed solution of 20 types of PFASs resulted in picking up 20 flag sets by fragmentation flagging. All the fragmentation flags were detected within a designated range of drift time, and their molecular ion was confirmed as a PFAS spiked in the standard solution even when co-eluting compounds were found at almost same retention time. This method was applied to a household fire extinguisher liquid, resulting in finding out nine molecular ions. Therefore, the new linking method achieved rapid searching for the prospective molecular ions using LC/IM-QTOF-MS.
ページの先頭へ

この画面を閉じる

Copyright (C) 2022 Independent Administrative Institution Public Works Research Institute